Research the connection between the cerebral edema after cerebral hemorrhage and AQP4mRNA expression, and the interferent effect of hirudin and nimotop. The ICH fashions were established by stereotaxic injecting of auto-non-anticoagulated artery blood into the caudate nucleus, detected AQP4mRNA expression by RT-PCR, international pharmacy and cerebral edema(cerebral water contents) after giving hirudin and nimotop. In contrast with the managed group, cerebral edema appeared in ICH group, hirudin group and nimotop group 6 h after cerebral hemorrhage (P 0.05), it reached peak at 3 d (P 0.05), elevated to (82.13±0.36), canadian online pharmacies (79.48±0.46) and (81.26±0.42) respectively, and cerebral edema of hirudin group, nimotop group have been lower than cerebral hemorrhage group (P 0.05). AQP4mRNA expression reached peak at 3 d (P 0.05), and the levels had been (1.34±0.14), (1.03±0.05) and medicine online shopping (1.27±0.14) respectively. There was a significantly positive correlation between BBB permeability and AQP4mRNA. AQP4mRNA expression elevated considerably after cerebral hemorrhage, which steered APQ4mRNA concerned in pathogenesis and improvement of cerebral edema, and international pharmacy hirudin, nimotop could inhibit cerebral edema.
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