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Monitoring should continue all through therapy and for four weeks after full discontinuation of Clozaril or till haematological recovery has occurred (see "Low WBC rely/ANC" below). At each consultation, the patient should be reminded to contact the treating physician immediately if any kind of infection, fever, sore throat or different flu-like symptoms develop. WBC and differential blood counts have to be performed instantly if any symptoms or indicators of an infection happen. If, during Clozaril therapy, both the WBC rely falls to between 3500/mm3 (3.5x109/l) and 3000/mm3 (3.0x109/l) or the ANC falls to between 2000/mm3 (2.0x109/l) and 1500/mm3 (1.5x109/l), haematological evaluations have to be performed no less than twice weekly until the affected person's WBC depend and ANC stabilise throughout the vary 3000-3500/mm3 (3.0-3.5x109/l) and 1500-2000/mm3 (1.5-2.0x109/l), respectively, or larger. Rapid discontinuation of Clozaril treatment is obligatory if both the WBC count is lower than 3000/mm3 (3.0x109/l) or the ANC is less than 1500/mm3 (1.5x109/l) during Clozaril remedy. WBC counts and differential blood counts should then be performed daily and patients needs to be rigorously monitored for flu-like signs or other symptoms suggestive of infection. Affirmation of the haematological values is advisable by performing two blood counts on two consecutive days; however, Clozaril must be discontinued after the primary blood depend. Following discontinuation of Clozaril, haematological analysis is required till haematological recovery has occurred.